The aim of the study is testing effectiveness of a program that meets the learning needs of gifted and talented students on students’ attitude towards Science and Technology course. For this purpose, one 5th grade unit in Science and Technology course named “Earth, Sun and Moon” was differentiated on the bases of scientific creativity skills and Parallel Curriculum and Grid Model. The study was conducted with a total number of 21 students; 11 of them being in the experimental group and 10 of them being in the control group. The subjects were 5th grade students of the public school, the only public primary school educating gifted students in the Istanbul Province. While the unit, named “Earth, Sun and Moon” was differentiated, was being taught to the experimental group, the same unit was being taught by the classroom teacher to the control group without any intervention. To collect data within the framework of this research, The Scale of Attitude towards Science (developed by Baykul, 1990) was used. The Scale of Attitude towards Science was administered as pre- and post-tests to the experimental and control groups. In the statistical analysis of data collected from these tests, mean, standard deviation, Mann Whitney-U and Wilcoxon Signed-Ranks Tests were used. The results of the study revealed that the differentiated science program, developed for the gifted and talented students, increased the attitude towards science scores of the subjects in experimental group. And especially gifted boys had statistically meaningful difference between pre and post test scores in the experimental group.